Nephrology and Hypertension Basic Research
Christopher Wilcox and William Welch’s Laboratory:
- Pathophysiology of renovascular hypertension.
- Mechanism of renal adaptation to high salt intake.
- Role of nitric oxide and oxidative stress in regulation of blood pressure, kidney function and single nephron glomerular filtration rate.
- Mechanisms of progressive loss of kidney funtion in models of chronic kidney disease.
- Role of isoprostanes, adenosine and vasoconstrictor prostaglandins in tubuloglomerular feedback and hypertension.
- Regulation of renal oxygenation by angiotensin and TP-receptors.
- Studies of the isolated perfused renal afferent arterioles and mesenteric resistance vessels.
- Renal myogenic and autoregulatory responses.
- Signal by microRNAs.
Kathryn Sandberg's Laboratory:
- Interaction of estrogens and sex hormones with the renin angiotensin system.
- G protein-coupled receptors.
- Ligand recognition.
- Post-transcriptional regulation.